STAIR VIII
Stroke Treatment Academic Industry Roundtable

March 9-10, 2013
Washington D.C.
 

"Accelerating the Evolution of Stroke Therapy"

STAIR VIII Program       STAIR VIII Sponsors      Consensus Recommendations       Presentation Slides

 

About STAIR VIII

STAIR VIII convened on March 9-10, 2013 at the Sheraton Pentagon City Hotel in Arlington, Virginia (Wash. DC).  Over sixty of the world’s leading stroke research neurologists and neuroradiologists actively participated in STAIR VIII. They were joined by an equal number of scientists and business leaders from pharmaceutical and device companies. Rounding out the consensus conference attendance was a large delegation of high level staff from NINDS and the FDA including CDER and CDHR branches.

The first day of the STAIR Conference was devoted to presentations providing updates of recently completed state-of-the-art stroke treatment research as well as prospective new studies and approaches on the horizon. Included in these presentations were the identification and discussion of issues to be addressed in the recommendation development portion of the STAIR consensus conference. These and related issues form the themes around which recommendations are generated which are intended to improve clinical studies and the overall R&D process from medical/scientific, regulatory and industry perspectives.

STAIR reserves large blocks of time following formal presentations at the end of each topic session for questions and discussion. A panel of experts representing the three sectors of academia, government and industry took the stage, after presentations in each session were completed, to pose questions to presenters and other experts covering information presented and issues posed. Open, candid interchange was facilitated by session co-chairs who invited questions and dialogue from participants in the audience as well as presenters and panelists. These discussions allowed complex issues to be rigorously explored via the knowledge, experience and perspective represented by and contributed from the diverse constituency of STAIR participants.

STAIR VIII Major Sessions and Presentations

  • MOVING FORWARD WITH ENDOVASCULAR REPERFUSION TRIALS
  • STROKE IMAGING RESEARCH ROADMAP
  • NEW ORAL ANTICOALGULANTS: UNRESOLVED ISSUES & NEXT STEPS
  • REGULATORY ISSUES RELEVANT TO STROKE TREATMENT AND PREVENTION TRIALS

Themes to be Addressed and Developed into STAIR VIII Consensus Recommendations

  • RECOMMENDATIONS FOR ENDOVASCULAR THERAPIES
  • RECOMMENDATIONS FOR IMAGING – THE STROKE IMAGING RESEARCH ROADMAP
  • RECOMMENDATIONS FOR NEW ORAL ANTICOAGULANTS

For complete information on sessions and presenters, consult the STAIR VIII Program.


The Stroke Imaging Repository (STIR) Consortium together with the The Foundation of the American Society of Neuroradiology are collaborating with the STAIR organization to help address important neuroimaging issues and insure that they are included in the STAIR VIII recommendations and publication.

About the STIR Consortium

In September 2007, the National Institute of Health, in conjunction with the American Society of Neuroradiology and The Foundation of the ASNR, sponsored a research symposium entitled Advanced Neuroimaging for Acute Stroke Treatment. That meeting brought together stroke neurologists, neuroradiologists, emergency physicians and neuroimaging research scientists to discuss the role of advanced neuroimaging in acute stroke treatment.
 
One of the recommendations was the creation of an international consortium of investigators – the Stroke Imaging Repository - to combine efforts to promote excellence in stroke care and stroke trial design and more specifically to overcome the issues faced by advanced stroke imaging, as mentioned earlier.

This central repository was designed to work in collaboration with two other collaborative groups, VISTA (Virtual International Stroke Trials Archive) and MR Stroke. VISTA is an international collaborative venture that was established to facilitate the planning of randomized clinical trials and collects and gathers datasets from multiple institutions. The VISTA database provides the possibility to access a large volume of patient data on which to perform original analyses that would ultimately aid clinical trial design and development.MR Stroke is a collaborative effort between leading clinicians and clinical scientists around the world with a common interest in Magnetic Resonance Imaging in Stroke. MR Stroke is intended to facilitate the sharing and exchange of information and ideas, to facilitate access to a range of web based MR imaging tools and resources relevant to stroke, and to establish a forum for the exchange of information relevant to research using MR Imaging in stroke.

STIR Goals

The overall purpose of STIR is to create a repository of source MRI and CT images that could be used towards the objectives of standardization and validation of image acquisition, of image analysis, and of clinical research methods for image-based stroke research. More specifically, the consortium was originally established to collect and provide a rich resource of patient datasets in order to contribute meaningful information regarding the goals listed above:

  1. Standardization of perfusion and penumbral imaging techniques
  2. Validation of the accuracy and clinical utility of imaging biomarkers of the ischemic penumbra
  3. Validation of imaging biomarkers relevant to clinical outcomes.

STIR information was extracted from Stroke Imaging Research Roadmap

Roadmap Authors:

Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S.

AJNR Am J Neuroradiol. 2008 May;29(5):e23-30

Go to Roadmap: Acute Stroke Imaging Research Roadmap


 

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